Reconstitution of the membrane protein OmpF into biomimetic block copolymer–phospholipid hybrid membranes

• Matthias Bieligmeyer,
• Franjo Artukovic,
• Stephan Nussberger,
• Thomas Hirth,
• Thomas Schiestel and
• Michaela Müller

Beilstein J. Nanotechnol. 2016, 7, 881–892, doi:10.3762/bjnano.7.80

• for the reconstitution of transmembrane proteins under preservation of protein function, independent of the membrane thickness. Keywords: biomimetics; block copolymer; lipopolymer mixture; OmpF reconstitution; self-assembly; Introduction Protein pores facilitate the transfer of molecules across

• expected. PIPEO block copolymer–phospholipid membranes As mixtures of PIPEO and DPhPC have not been analyzed before, the ability of this type of lipopolymer mixture to form membranes, as well as the appearance and the characteristics of these membranes were examined. To assess the miscibility of PIPEO and